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KMID : 0043320160390101433
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Archives of Pharmacal Research
2016 Volume.39 No. 10 p.1433 ~ p.1440
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Preparation and activity evaluation of chrysin-β-d-galactopyranoside
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Zhu Zhen Yuan
Chen Ling
Liu Fei
Chen Li Jing
Meng Meng
Sun Hui Qing
Zhang Yong Min
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Abstract
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Chrysin-β-d-galactopyranoside was efficiently synthesized, evaluated for its inhibitory activities against H22 cell lines compared with chrysin, the scavenging of hydroxyl radical, DPPH radical and superoxide anion, inhibitory effect against bacteria and fungi. The structures of all compounds were fully characterized by spectroscopic data (NMR, MS). The anti-tumor, antioxidant and antimicrobial activities of chrysin-β-d-galactopyranoside were proved to be enhanced significantly compared with chrysin.
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KEYWORD
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Chrysin, Glycosylation, Derivative, Antitumor activity, Antioxidant activity, Antimicrobial activity
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